Lubiprostone is used to treat adults with chronic idiopathic constipation or opiate agonist-induced constipation (OIC), and is also used in adult women with constipation-predominant irritable bowel syndrome (IBS-C). Chemically, the drug is a bicyclic fatty acid, prostaglandin E1 (PGE 1) derivative that increases intestinal fluid secretion by activating specific ClC-2 chloride channels in the luminal cells of the intestinal epithelium. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach.Lubiprostone is a unique gastrointestinal agent for the treatment of constipation. It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. See the FDA's Safe Disposal of Medicines website ( ) for more information if you do not have access to a take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. Instead, the best way to dispose of your medication is through a medicine take-back program. However, you should not flush this medication down the toilet. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. Store it at room temperature and away from light, excess heat and moisture (not in the bathroom). Keep this medication in the container it came in, tightly closed, and out of reach of children. If your breastfed child has diarrhea while you are taking lubiprostone, call your doctor. tell your doctor if you are breastfeeding.If you become pregnant while taking lubiprostone, call your doctor right away. Talk to your doctor about the method of birth control that is best for you. You must use birth control while taking this medication. You will need to have a negative pregnancy test before you begin to take lubiprostone. tell your doctor if you are pregnant or plan to become pregnant.tell your doctor if you have severe diarrhea or liver disease.If you have this type of blockage, your doctor will probably tell you not to take lubiprostone. If you do not know if you have a blockage in your stomach or bowels, your doctor will examine you to see whether you have this condition. tell your doctor if you have or have ever had a blockage in your stomach or bowels.Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Be sure to mention any of the following: medications for high blood pressure and methadone (Dolophine, Methadose). tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.

Ask your pharmacist for a list of the ingredients. tell your doctor and pharmacist if you are allergic to lubiprostone, any other medications, or any of the ingredients in lubiprostone capsules.

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